Increasing antimicrobial resistance is a major and complex public health issue requiring a multifaceted action plan.1, 2 Antimicrobial stewardship programs, by improving the appropriate use of antimicrobials, are one of the main initiatives put forward to tackle this problem.3, 4 An important group of patients that needs to be targeted comprises those allergic to penicillin, who make up around 10% of the adult population.5, 6, 7 These patients are more at risk of being infected by Clostridium difficile or colonized by resistant bacteria such as methicillin-resistant Staphylococcus aureus or vancomycin-resistant Enterococcus.6, 8 In addition, they have higher treatment failure rates for certain types of infections.
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